Phosphatidylinositol Triphosphate Kinase-dependent and c-Jun NH2-Terminal Kinase-dependent Induction of Telomerase by Calcium Requires Pyk2

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Phosphatidylinositol triphosphate kinase-dependent and c-jun NH2-terminal kinase-dependent induction of telomerase by calcium requires Pyk2.

Calcium signaling has been linked to activation of Pyk2, a calcium-dependent, focal adhesion kinase-related, non-receptor tyrosine kinase. Signaling via Pyk2 can activate c-jun NH(2)-terminal kinase (JNK). Calcium has also been shown to activate phosphatidylinositol triphosphate kinase and/or JNK. Here, we show that calcium signaling in ovarian surface epithelial cells not only induces telomera...

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ژورنال

عنوان ژورنال: Cancer Research

سال: 2004

ISSN: 0008-5472,1538-7445

DOI: 10.1158/0008-5472.can-03-2820